Table 2.
Significant associations between TCF7L2 SNPs and breast cancer risk, The Breast Cancer Health Disparities Study
| TCF7L2 | Genotypes | Overall
|
|||
|---|---|---|---|---|---|
| Cases/controls | OR (95 % CI) | Wald P | Padj | ||
| rs1225404 | TT | 1561/1735 | 1.00 | 0.0149 | 0.0457 |
| CT | 1564/1921 | 0.92 (0.83–1.01) | |||
| CC | 399/552 | 0.82 (0.70–0.94) | |||
| rs3750805 | AA | 2663/3292 | 1.00 | 0.0098 | 0.0420 |
| AT/TT | 861/917 | 1.15 (1.03–1.28) | |||
| rs7900150 | TT | 1377/1780 | 1.00 | 0.0139 | 0.0457 |
| TA | 1559/1849 | 1.04 (0.94–1.16) | |||
| AA | 587/579 | 1.23 (1.07–1.42) | |||
| rs7903146 | CC | 1961/2483 | 1.00 | 0.0369 | 0.0474 |
| CT | 1304/1476 | 1.09 (0.99–1.20) | |||
| TT | 258/250 | 1.24 (1.03–1.49) | |||
| rs12255372a | GG | 2041/2552 | 1.00 | 0.1567 | 0.1567 |
| GT | 1252/1431 | 1.05 (0.95–1.16) | |||
| TT | 229/226 | 1.20 (0.99–1.46) | |||
| Haplotype | |||||
| rs7081062 | |||||
| rs7903146 | |||||
| rs7900150 | Copies | ||||
| A-T-A | 0 | 3088/3790 | 1.00 | 0.0155 | |
| 1 | 211/215 | 1.16 (0.95–1.42) | |||
| 2 | 225/204 | 1.30 (1.06–1.58) | |||
OR (odds ratios) and 95 % confidence interval (CI) adjusted for age, study, and genetic admixture
a
rs12255372 is presented to compare its main effects with other breast cancer studies