Table 3.
Interaction between TCF7L2, history of Type 2 diabetes, and breast cancer risk, The Breast Cancer Health Disparities Study
| TCF7L2 | Genotype | Diabetes history Cases = 399/controls = 508 OR (95 % CI) |
No diabetes history Cases = 2714/controls = 3244 OR (95 % CI) |
Pinteraction | P(adj) |
|---|---|---|---|---|---|
| rs3750804 | CC | 1.00 | 1.00 | 0.0043 | 0.0086 |
| CT | 0.81 (0.61–1.08) | 1.09 (0.97–1.21) | |||
| TT | 2.46 (1.28–4.73) | 1.06 (0.85–1.32) | |||
| rs3814570 | CC | 1.00 | 1.00 | 0.0099 | 0.0099 |
| CT/TT | 0.76 (0.58–0.99) | 1.13 (1.02–1.26) |
OR (odds ratios) and 95 % confidence interval (CI) adjusted for age, study, BMI in referent year, and genetic admixture