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A mixed meal containing [1-13C] glucose was ingested at time 0 (a). A primed-continuous infusion of [6,6 2H2] glucose was started at time −120 min and then varied from time 0 onward to mimic the anticipated pattern of change of endogenous glucose production (b). An intravenous infusion of [6-3H] glucose was started at time 0, and the rate varied to mimic the anticipated pattern of appearance of the ingested glucose (c) [29].
