Table 2.

Baseline predictors of time from index date to opioid rotation during the first year after index date for oxycodone and morphine together

Predictor	Hazard ratio (95% CI)	P
Age at index date (by 10 years)a	0.97 (0.95–0.98)	<0.001
Age category at index date	0.87 (0.83–0.91)	<0.001
(<65/≥65 years)
Sex (1 = male, 2 = female)	1.08 (1.03–1.14)	<0.01
Non-cancer diagnoses
Fibromyalgia	1.01 (0.95–1.08)	0.67
Low back pain	0.99 (0.93–1.04)	0.59
Other spinal painb	1.03 (0.90–1.19)	0.63
Osteoarthritis	1.05 (1.00–1.11)	<0.05
Other musculoskeletal pain	0.92 (0.87–0.96)	<0.001
Neuropathic pain	0.98 (0.93–1.03)	0.37
Concomitant drugs (n)c,d	1.00 (0.99–1.00)	0.30
Pain-related drugs (n)d	0.92 (0.91–0.94)	<0.001

Notes:

^aFor every 10-year increase in age, there could be a lower risk, higher risk, or no risk;

^bexcluding low back and including neck pain;

^cas a proxy for comorbidity;

^dfor every extra drug, there could be a lower risk, higher risk, or no risk.

Abbreviation: CI, confidence interval.