Table 1.
Timeline of the clinical course
| Date | Clinical course | Therapy |
|---|---|---|
| November 2004 |
Diagnosis of usual interstitial pneumonia (UIP) |
|
| August 2009 |
|
Double lung transplantation, complicated postoperative course |
| November 2009 |
Rehabilitation treatment |
|
| December 2009 - January 2010 |
Persistent cough |
Admission to general hospital |
| 3.1.2010 |
Aggravation of general/ respiratory condition |
Admission to intensive care unit |
| Respiratory insufficiency |
Intubation |
|
| 5.1.2010 |
Nasotracheal secretion positive for viral influenza A/H1N1 RNA (working diagnosis: H1N1 pneumonia with bacterial superinfection) |
Meropenem, clarithromycin and oseltamivir |
| 7.1.2010 |
Detection of viral influenza A/H1N1 RNA by real-time PCR (bronchoscopy) |
|
| Detection of mutation causing resistence against oseltamivir |
Switch from oseltamivir to zanamivir |
|
| Acute renal failure |
Continuous venous-venous hemofiltration |
|
| 8.1.2010 |
Respiratory insufficiency |
Extracorporeal interventional lung assist implantation |
| 11.1.2010 | Rapidly progressive respiratory failure | Death |