Table 3.
Frequency of major leukocyte subsets from patient with mutation in TRPV3 and age-matched healthy controls
|
Subset |
Defining surface markers |
Patient (%) |
Healthy volunteers (%) |
|
|---|---|---|---|---|
| Mean (SD) | Median (min-max) | |||
| T cells |
CD3+ |
25.0 |
21.7 (10.7) |
20.2 (8.48-41.6) |
| B cells |
CD19+ |
25.7 |
28.9 (11.5) |
26.5 (16.9-55.1) |
| γδ T cells |
γδ TCR+ |
0.25 |
0.23 (0.21) |
0.15 (0.04-0.72) |
| iNKT cells |
CD3+Vα24Jα18+ |
0.49 |
0.52 (0.25) |
0.55 (0.09-0.89) |
| NKT cells |
CD3+CD56+ |
2.49 |
10.2 (4.91) |
9.35 (4.15-16.8) |
| NK cells |
CD3-CD19-CD14-CD11c-CD56+ |
22.0 |
21.2 (10.1) |
18.2 (9.17-40.8 |
| Dendritic cells |
CD3-CD19-CD14-CD56- |
6.67 |
6.66 (2.76) |
6.21 (2.96-11.4) |
| →mDC |
CD11c+HLA-DR+ |
35.5 |
41.4 (6.17) |
42.2 (31.8-55.4) |
| →pDC | CD11c-CD123+ | 21.3 | 16.8 (10.9) | 19.9 (3.88-39.25) |
T cells are shown as percentage total leukocytes; B cells and γδ T cells are shown as percentage total lymphocytes; iNKT and NKT cells as percentage T cells; NK cells and dendritic cells are shown as percentage total leukocytes while mDC and pDC are shown as percentage dendritic cells.