Table 2.
Comparison of patients with LMNA gene mutation and stroke
| Author | Age of stroke | Stroke signs | Stroke location | Arrhythmia during all follow-up | Pacemaker insertion and age | Phenotype | Mutation of LMNA gene |
|---|---|---|---|---|---|---|---|
| Onishi et al., 2002 [11] |
45 |
Right hemiplegia |
N/A |
AF, AVB, VPC |
Pacemaker, 45 |
AD-EDMD |
p.Ser303Pro (c.907 T>C) |
| Boriani et al., 2003 [4] |
26 |
Hemiplegia |
N/A |
AF, AFL, AVB |
VVI, 30 |
AD-EDMD |
p.Arg386Lys (c.1157 G>A) |
| 57 and 70 |
N/A |
N/A |
AF, AVB, SAB |
VVI, 55 |
AD-EDMD |
p.Arg527Pro (c.1580 G>C) |
|
| 43 and 44 |
Ataxia |
Cerebellum |
AF, AVB |
VVI, 41 |
AD-EDMD |
p.Arg377Leu (c.1130 G>T) |
|
| Liang et al., 2007 [12] |
45 |
Conscious loss |
Pons |
VPC, VT, VF |
nil |
AD-EDMD |
p.Trp520Gly (c.1558 T>G) |
| Redondo-Vergé et al., 2011 [13] |
25 |
Aphasia, right hemiparesis |
Left MCA |
AF, AVB |
ICD, 25 |
AD-EDMD |
p.Arg89Leu (c.266 G>T) |
| Tanaka et al., 2012 [14] |
12 |
Dysarthria, left hemiparesis |
Right MCA |
AF |
nil |
AD-EDMD |
N/A |
| Present case | 39 | Aphasia, right hemiplegia | Left MCA | AF, RBBB, AVB | VVI, 37 | LGMD1B | c.IVS2+1 G>A (c.513+1 G>A) |
AF atrial fibrillation, AVB atrioventricular block, ICD implantable cardioverter defibrillator, MCA middle cerebral artery, N/A non available, SAB sinoatrial block, VPC ventricular paroxysmal contraction, VT ventricular tachycardia.