Table 5.
Aggregate NCI 60-cell-line screening results.
| Compd | Mean GP [%]a | Lowest GP [%]b | Highest GP [%]c |
|---|---|---|---|
| ML240 | −84.5±15.5 | −100.0 (OVCAR-4) | −43.8 (HS 578T) |
| ML241 | 92.8±22.8 | 111.9 (HS 578T) | 69.9 (MDA-MB-231/ATCC) |
a
Growth percent (GP) for individual cell lines calculated as follows: for negative growth, GP=100×(ODtest−ODT=0)/ODT=0; for positive growth, GP=100×(ODtest−ODT=0)/(ODcontrol−ODT=0), for which GP is growth percent, ODtest is the optical density of the test culture after 48 h, ODT=0 is the optical density of the test culture before addition of compound, and ODcontrol is the optical density of the control culture after 48 h; values represent the mean of 60 NCI cell lines ±SD.
b
Growth percent of the most inhibited individual cancer cell line.
c
Growth percent of the least inhibited individual cancer cell line.