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Inhibition of either ADAM-17 or γ-secretase reduces proliferation of renal carcinoma cell lines. A–B: 786-O (A) and OS-RC-2 (B) were treated with either Marimastat or DAPT at different doses then proliferation was measured by CCK-8 assay, the control group is no treatment. The mean cell activity (OD) of three experiments is presented (P<0.05). C: Expression of 786-O cells in the transwell assay by different doses of two types of inhibitor treatment cells.
