Table 5.
Univariable associations of infarct size determined by various methods with 90-day composite of mortality, heart failure, shock and stroke
| Method |
COMMA trial |
COMPLY trial |
||
|---|---|---|---|---|
| Hazard ratio (95% CI) | Wald χ 2 ( P value) | Hazard ratio (95% CI) | Wald χ 2 ( P value) | |
| Total CK-MB AUC 0 to 72 hours from randomization estimated by curve modelinga |
|
|
|
|
| per 1000 units |
1.14 |
53.08 |
1.08 |
48.31 |
| (1.10 to 1.18) |
(<0.001) |
(1.06 to 1.11) |
(<0.001) |
|
| per 1 SD |
1.74 |
|
1.51 |
|
| (1.50 to 2.02) |
|
(1.35 to 1.70) |
|
|
| Estimated peaka |
|
|
|
|
| per 100 units |
1.03 |
15.34 |
1.11 |
29.87 |
| (1.02 to 1.05) |
(<0.001) |
(1.07 to 1.15) |
(<0.001) |
|
| per 1 SD |
1.15 |
|
1.36 |
|
| (1.07 to 1.24) |
|
(1.22 to 1.53) |
|
|
| Observed trapezoidal CK-MB AUC |
|
|
|
|
| per 1000 units |
1.15 |
55.76 |
1.09 |
50.26 |
| (1.11 to 1.19) |
(<0.001) |
(1.06 to 1.11) |
(<0.001) |
|
| per 1 SD |
1.79 |
|
1.53 |
|
| (1.53 to 2.08) |
|
(1.36 to 1.73) |
|
|
| Observed peak |
|
|
|
|
| per 100 units |
1.26 |
45.96 |
1.11 |
30.05 |
| (1.18 to 1.34) |
(<0.001) |
(1.07 to 1.16) |
(<0.001) |
|
| per 1 SD | 1.72 |
|
1.36 |
|
| (1.47 to 2.01) | (1.22 to 1.52) | |||
aEstimated from the log-normal model. AUC, area under the curve; CI, confidence interval; CK, creatine kinase; COMMA, COMplement inhibition in Myocardial infarction treated with Angioplasty; COMPLY, COMPlement inhibition in myocardial infarction treated with thromboLYtics; SD, standard deviation.