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. 2013 May 23;9(5):e1003363. doi: 10.1371/journal.ppat.1003363

Figure 5. Hypothetical model for formation of AS1-RS1 intra-genomic long-range RNA-RNA interaction.

Figure 5

(A) Linear representation of lD2. (B) Folding of the internal region of lD2 brings AS1 and RS1 (red nucleotides) in proximity and base pairing between these sequences initiates the interaction (red arrow). (C) Melting of the AS1 stem permits it to pair with sequences flanking RS1 (blue and gold nucleotides), thereby allowing for completion of domain formation (as depicted by the green dotted oval).