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. 2013 May 23;8(5):e64248. doi: 10.1371/journal.pone.0064248

Table 1. GREAT Analysis of Runx1 and p300 co-bound genomic regions show highly significant overrepresentation of genes with important roles in megakaryopoiesis and platelet function.

Enriched term Raw P-values FDR Q-values
Mouse phenotype
Abnormal platelet physiology 7.87 e-24 2.41 e-10
Abnormal platelet activation 5.46 e-20 1.49 e-6
Decreased platelet aggregation 2.87 e-18 1.74 e-6
Abnormal megakaryocyte progenitor cell morphology 5.78 e-15 1.13 e-5
Abnormal blood coagulation 1.28 e-16 6.68 e-8
Abnormal megakaryocyte morphology 1.73 e-14 2.32 e-4
Decreased platelet cell number 2.08 e-14 6.03 e-5
Abnormal thrombopoiesis 3.97 e-14 4.63 e-5
Abnormal megakaryocyte differentiation 1.83 e-11 4.1 e-3
Disease Ontology
Blood platelet disease 4.57 e-14 3.2 e-4
Hemorrhagic disease 1.23 e-12 2.72 e-4
Blood coagulation disease 4.29 e-12 3.49 e-4
Thrombocytopenia 1.02 e-6 3.3 e-2