Table 1. GREAT Analysis of Runx1 and p300 co-bound genomic regions show highly significant overrepresentation of genes with important roles in megakaryopoiesis and platelet function.
Enriched term | Raw P-values | FDR Q-values |
Mouse phenotype | ||
Abnormal platelet physiology | 7.87 e-24 | 2.41 e-10 |
Abnormal platelet activation | 5.46 e-20 | 1.49 e-6 |
Decreased platelet aggregation | 2.87 e-18 | 1.74 e-6 |
Abnormal megakaryocyte progenitor cell morphology | 5.78 e-15 | 1.13 e-5 |
Abnormal blood coagulation | 1.28 e-16 | 6.68 e-8 |
Abnormal megakaryocyte morphology | 1.73 e-14 | 2.32 e-4 |
Decreased platelet cell number | 2.08 e-14 | 6.03 e-5 |
Abnormal thrombopoiesis | 3.97 e-14 | 4.63 e-5 |
Abnormal megakaryocyte differentiation | 1.83 e-11 | 4.1 e-3 |
Disease Ontology | ||
Blood platelet disease | 4.57 e-14 | 3.2 e-4 |
Hemorrhagic disease | 1.23 e-12 | 2.72 e-4 |
Blood coagulation disease | 4.29 e-12 | 3.49 e-4 |
Thrombocytopenia | 1.02 e-6 | 3.3 e-2 |