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. 2013 May 23;8(5):e63888. doi: 10.1371/journal.pone.0063888

Figure 1. Schematic depicting the eleven members of the pvmsp3 gene family in chromosome 10 and characteristic features of all PvMSP3 family members.

Figure 1

1A. Pvmsp3 gene family members are arranged in tandem in chromosome 10, and flanked by unrelated loci (PVX_097665 and PVX_097730). The eleven pvmsp3 genes are represented as open boxes and labeled as pvmsp3.1 through pvmsp3.11. The gene IDS are: PVX_097670, PVX_097675, PVX_097680, PVX_097685, PVX_097690, PVX_097695, PVX_097700, PVX_097705, PVX_097710, PVX_097720, PVX_097725, respectively. The originally described pvmsp3 family members (α, β and γ) are also marked as such. One ORF, PVX_097715, does not encode characteristic features of PvMSP3 proteins (Fig. 2) and has thus been excluded as a member of the pvmsp3 gene family. 1B. Each PvMSP-3 is depicted with the protein’s size in amino acids noted. The predominant centrally located coiled-coil structures of each protein are depicted by blue coiled cylinders. Other characteristic features include a conserved NLRNG motif (triangle) near the N-terminus and a glutamate-rich motif (red rectangles) near the C-terminus. Putative signal peptides (green) are marked by arrows at the N-termini and purple lines below each protein schematic underscores the regions expressed as recombinant proteins. The calculated molecular weights of these recombinant proteins are noted in Table 1.