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. Author manuscript; available in PMC: 2013 May 23.
Published in final edited form as: Pigment Cell Melanoma Res. 2011 Nov 14;25(1):88–98. doi: 10.1111/j.1755-148X.2011.00916.x

Figure 1.

Figure 1

Inducible Hsp70 knockout mice are resistant to depigmentation after TRP-1 vaccination. (A) Wild-type (WT) and Hsp70-1 knockout (Hsp70-1 KO) mice were gene gun vaccinated five times every six days with DNA encoding either 6 μg of optimized TRP-1 or 3 μg each of optimized TRP-1 and HSP70i and imaged 4 weeks after the final vaccination. (B) Image analysis indicates that wild-type mice depigment significantly more compared to the Hsp70-1 KO mice after either vaccination (vacc), indicating that expression of HSP70i is required for efficient induction of autoimmunity. Data are presented as means ± SEM. (*P < 0.05; ***P < 0.001; n = 10 per group.)