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. Author manuscript; available in PMC: 2013 May 23.
Published in final edited form as: Pigment Cell Melanoma Res. 2011 Nov 14;25(1):88–98. doi: 10.1111/j.1755-148X.2011.00916.x

Figure 4.

Figure 4

HSP70i accelerates depigmentation in vitiligo-prone mice. (A) Wild-type (WT) and Pmel-1 mice were vaccinated three times every 7 days with 4 μg of either HSP70i encoding or empty vector (EV) control DNA. Depicted are ventral and dorsal images of representative vaccinated animals six months after the final gene gun vaccination. Depigmentation in wild-type mice occurred within and distal to the site of the gene gun vaccination (B) Upon quantification, Pmel-1 mice receiving HSP70i-encoding DNA displayed significantly more depigmentation compared to control vaccinations and vaccinations in wild-type mice, confirming that focal overexpression of HSP70i is sufficient to induce vitiligo in disease-prone animals. Data are presented as means ± SEM. (**P < 0.01; ***P < 0.001; n = 3 per group.)