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. Author manuscript; available in PMC: 2014 Apr 26.
Published in final edited form as: Biochem Biophys Res Commun. 2013 Mar 29;434(1):70–74. doi: 10.1016/j.bbrc.2013.03.064

Figure 3. Knockdown of HMGA1 in MDA-MB-231 breast cancer cells impairs tumorigenesis and metastasis in immunodeficient mice.

Figure 3

A) Primary tumor size in immunodeficient mice injected with control or HMGA1-silenced (HMGA1-) MDA-MB-231 breast cancer cells; values shown are means ± SD; n = 10. B) Histological analysis shows extensive metastases in the lungs of mice injected with control cells, and only small metastases or intravascular neoplastic emboli in the lungs of animals injected with HMGA1-silenced cells; two representative mice from each cohort, and two magnifications for each slide are shown. C) Representative lymph node from one mouse injected with control cells; the lymph node is expanded and largely effaced by neoplastic cells.