Table 3.
Analysis of primary outcome of diagnosis of diabetes in Ontario Diabetes Database in new users of statins
| Statin | No of patients | No of outcomes | Median (IQR) follow-up (person days) | No of outcomes per 1000 person years | HR (95% CI) | Number needed to treat to harm | |
|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted* | ||||||
| All users | |||||||
| Pravastatin | 38 470 | 1443 | 240 (90-1095) | 22.64 | Reference | Reference | — |
| Atorvastatin | 268 254 | 15 261 | 369 (90-1283) | 30.70 | 1.37 (1.30 to 1.44) | 1.22 (1.15 to 1.29) | 172 |
| Fluvastatin | 5636 | 167 | 190 (67-742) | 21.52 | 0.94 (0.80 to 1.10) | 0.95 (0.81 to 1.11) | — |
| Lovastatin | 6287 | 211 | 210 (90-945) | 21.80 | 0.96 (0.83 to 1.11) | 0.99 (0.86 to 1.14) | — |
| Rosuvastatin | 76 774 | 3732 | 308 (58-806) | 34.21 | 1.50 (1.41 to 1.59) | 1.18 (1.10 to 1.26) | 210 |
| Simvastatin | 75 829 | 3727 | 331 (90-1384) | 26.22 | 1.17 (1.10 to 1.24) | 1.10 (1.04 to 1.17) | 363 |
| Primary prevention users | |||||||
| Pravastatin | 17 901 | 637 | 205 (72-975) | 22.80 | Reference | Reference | |
| Atorvastatin | 124 925 | 6902 | 300 (64-1207) | 31.45 | 1.39 (1.29 to 1.51) | 1.20 (1.10 to 1.30) | 181 |
| Fluvastatin | 3066 | 91 | 180 (63-799) | 22.34 | 0.97 (0.77 to 1.20) | 0.98 (0.79 to 1.22) | — |
| Lovastatin | 3241 | 110 | 206 (90-945) | 22.11 | 0.97 (0.79 to 1.18) | 1.01 (0.82 to 1.23) | — |
| Rosuvastatin | 46 591 | 2240 | 285 (37-772) | 34.92 | 1.51 (1.39 to 1.65) | 1.12 (1.02 to 1.23) | 294 |
| Simvastatin | 32 270 | 1552 | 274 (80-1233) | 27.41 | 1.21 (1.11 to 1.33) | 1.12 (1.02 to 1.23) | 294 |
| Secondary prevention users | |||||||
| Pravastatin | 20 569 | 806 | 279 (90-1176) | 22.51 | Reference | Reference | — |
| Atorvastatin | 143 329 | 8359 | 425 (90-1349) | 30.11 | 1.35 (1.25 to 1.45) | 1.25 (1.16 to 1.34) | 162 |
| Fluvastatin | 2570 | 76 | 202 (71-787) | 20.62 | 0.91 (0.72 to 1.15) | 0.91 (0.72 to 1.15) | — |
| Lovastatin | 3046 | 101 | 214 (90-941) | 21.48 | 0.95 (0.77 to 1.16) | 0.97 (0.79 to 1.20) | — |
| Rosuvastatin | 30 183 | 1492 | 350 (60-858) | 33.18 | 1.47 (1.34 to 1.60) | 1.24 (1.13 to 1.36) | 168 |
| Simvastatin | 43 559 | 2175 | 382 (90-1490) | 25.44 | 1.14 (1.05 to 1.23) | 1.10 (1.01 to 1.19) | 407 |
*Adjusted for age, sex, year of cohort entry, recent acute coronary syndrome, chronic coronary artery disease, Charlson score, previous use of diuretic (thiazide), nitroglycerin, angiotensin receptor blocker, β blocker, hormones and analogues.