Table 5.
Analysis of primary outcome of diagnosis of diabetes in Ontario Diabetes Database by drug and dose in new users of statins. Figures are hazard ratios (95% confidence intervals)
| Statin | Unadjusted | Adjusted* |
|---|---|---|
| Pravastatin | Reference | Reference |
| Atorvastatin | 1.21 (1.15 to 1.28) | 1.12 (1.05 to 1.18) |
| Fluvastatin | 0.94 (0.80 to 1.10) | 0.94 (0.80 to 1.11) |
| Lovastatin | 0.96 (0.83 to 1.11) | 0.99 (0.85 to 1.14) |
| Rosuvastatin | 1.21 (1.13 to 1.30) | 1.01 (0.94 to 1.09) |
| Simvastatin | 1.16 (1.09 to 1.24) | 1.11 (1.04 to 1.18) |
| Dose grouping: | ||
| Low dose† | Reference | Reference |
| Moderate dose‡ | 1.26 (1.22 to 1.30) | 1.22 (1.19 to 1.26) |
| High dose§ | 1.39 (1.29 to 1.50) | 1.30 (1.20 to 1.40) |
*Adjusted for age, sex, year of cohort entry, recent acute coronary syndrome, chronic coronary artery disease, Charlson score, and previous use of diuretic (thiazide), nitroglycerin, angiotensin receptor blocker, β blocker, hormones and analogues.
†Atorvastatin <20 mg, fluvastatin all doses, lovastatin all doses, pravastatin all doses, rosuvastatin <10 mg, simvastatin <80 mg.
‡Atorvastatin 20-<80 mg, rosuvastatin 10-<40 mg, simvastatin ≥8 0mg.
§Atorvastatin ≥80 mg, rosuvastatin ≥40 mg.