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miR-100 is involved in aberrant IGF signaling pathway activation. (A) miR-100 expression among 89 HCCs is overall decreased in samples exhibiting phosphorylation of IGF-1R. (B) miR-100 expression decrease using an anti-mR-100 inhibitor in HCC cell lines. (C) Inhibition of miR-100 expression in Hep3B cells enhanced IGF-1R activation 24 hours post-transfection.
