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. Author manuscript; available in PMC: 2013 Nov 8.
Published in final edited form as: Neuron. 2013 Apr 11;78(3):498–509. doi: 10.1016/j.neuron.2013.02.036

Figure 2. Neuroligin-3 R451C substitution enhances GABAergic synaptic transmission in CCK basket cell synapses.

Figure 2

(A) Paired recordings of presynaptic APs in CCK basket cells (upper traces) that produce unitary IPSCs in CA1 pyramidal cells (lower traces, Vholding = −70 mV). (B) Comparison of IPSC amplitudes (including failures) and of the percentages of successful transmissions induced by presynaptic APs applied at 1, 5, and 10 Hz in wild-type and R451C-mutant synapses. Open circles represent individual pairs (nWT=8, nR451C=17, Mann-Whitney RST, P=0.013 at 1 Hz IPSCs and P>0.08 in all other data sets). (C & D) No change in IPSC halfwidth (nWT=8, nR451C=15, Mann-Whitney RST, P=0.098) and no increase in the minimal IPSC amplitudes in R451C KI (nWT=8, nR451C=15, Mann-Whitney RST, P=0.5) suggest that the enhanced IPSC amplitudes in R451C KIs is not due to changes in quantal GABA receptor responses. (E) The frequency of finding synaptically coupled pairs was not altered in R451C mice. (F) Neurolucida reconstructions of biocytin-filled basket cells show no major reorganization in axonal and dendritic arbor of CCK basket cells.