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. Author manuscript; available in PMC: 2013 Nov 8.
Published in final edited form as: Neuron. 2013 Apr 11;78(3):498–509. doi: 10.1016/j.neuron.2013.02.036

Figure 4. Neuroligin-3 KO enhances GABAergic synaptic transmission in CCK basket cell synapses similar to the R451C KI.

Figure 4

(A & B) Paired recording data show that IPSC amplitudes and transmission rates were enhanced in CCK basket cell to CA1 pyramidal neuron synapses at multiple AP firing frequencies (nWT=28, nKO=36, Mann-Whitney RST, P=0.12 at 10 Hz IPSCs, and P<0.03 for all other data set). (C) Increase in IPSC halfwidth in KO suggest possible subunit reorganization of GABA receptor subunits in NL3 KO (nWT=28, nKO=35, Mann-Whitney RST, P=0.021). (D & E) No change in minimal IPSC amplitudes (nWT=28, nKO=35, Mann-Whitney RST, P=0.885), and in the frequency of finding connected pairs between CCK basket cells and pyramidal cells.