Skip to main content
. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Biochem J. 2012 Jul 15;445(2):229–236. doi: 10.1042/BJ20120053

Figure 6. Schematic of the effects of Rac1, SP-1, and ERK on MMP-9 expression.

Figure 6

Rac1 decreases SP-1 protein stability by inhibition of ERK. ERK modulates SP-1 degradation via S586 in the PEST domain. SP-1 is critical for MMP-9 expression in alveolar macrophages. This provides a mechanism by which Rac1 modulates macrophage-derived MMP-9 expression and activity.