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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: J Biophotonics. 2009 Sep;2(0):528–539. doi: 10.1002/jbio.200910046

Figure 3.

Figure 3

Optical imaging of microanatomy of the fresh lymph node ex vivo obtained with optical clearance using 80% glycerol. The central schematic designed by David Sabio [44] shows a midsagital section of a lymph node containing three lymphoid lobules with the basic anatomical and functional unit of the lymph node. Top and middle lobules: microanatomical schematics of lobular compartments (superficial cortex, deep cortex and medulla) without (top) and with (middle) reticular meshwork. Bottom lobule: a lobule of a mouse lymph node as it appears in conventional histological section. C1 shows basophilic lymphocytes; C2 shows elongated fibroblastic reticular cells; and C3 shows B lymphocytes and follicular dendritic cells (see other details in SD # 3).