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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: J Biophotonics. 2009 Sep;2(0):528–539. doi: 10.1002/jbio.200910046

Figure 5.

Figure 5

Targeted laser purging of SLN metastasis. (a–c) Laser ablation of MDA-MB-231 breast cancer cells labeled by GNT-folate conjugates: linear PT response from live cell (left), non-linear PT response from damaged cell (middle), and the disappearance of PT signal after cell disintegration by high energy laser pulse as feedback control of therapeutic efficacy (right). (d) Laser targeted ablation of single breast cancer cells double labeled by GNT-folate and FITC injected in the lymph node ex vivo (left) was verified at single cell level by fluorescent microscopy (middle). The right image indicates the zone of the high local destruction (40×30 μm) within the lymph node after cancer cell elimination.