Table 2.

Drugs and their Kpuu, CSF and Kpuu, brain values obtained in animals (rats, sheep, rabbits, rhesus monkeys, and nonhuman primates) on the basis of steady state (SS) values, AUC values, continuous infusion (cont inf)

Compound	Species	Time	Kpuu, CSF	Kpuu, brain	Reference
9-OH-Risperidone	Rat	6 h cont inf	0,0684	0,0143	[61]
Acetaminophen	Rat	AUC (partial)	0,3	1,2	[25]
Alovudine	Rat	SS	0,4	0,16	[72]
Antipyrine	Rat	2 h cont inf	0,99	0,708	[56]
Atomoxetine	Rat	SS	1,7	0,7	[64]
Baclofen	Rat	Pseudo SS	0,028	0,035	[73]
Benzylpenicillin	Rat	2 h cont inf	0,0134	0,0264	[56]
Buspirone	Rat	2 h cont inf	0,558	0,612	[56]
Caffeine	Rat	2 h cont inf	1,03	0,584	[56]
Carbamazepine	Rat	2 h cont inf	0,535	0,771	[56]
Carbamazepine	Rat	6 h cont inf	0,167	0,232	[61]
Carboplatin	Nonhuman primate	AUC	0,05	0,05	[74]
Cefodizime	Rat	Specific time	0,02	0,22	[75]
Ceftazidime	Rat	SS	0,039	0,022	[76]
Ceftriaxone	Rat	SS	0,71	0,8	[76]
Cephalexin	Rat	2 h cont inf	0,0225	0,016	[56]
Cimetidine	Rat	2 h cont inf	0,0211	0,00981	[56]
Cisplatin	Nonhuman primate	AUC	0,05	0,05	[74]
Citalopram	Rat	2 h cont inf	0,667	0,494	[56]
Citalopram	Rat	6 h cont inf	0,5	0,559	[61]
CP-615,003	Rat	SS	0,01	0,0014	[77]
Daidzein	Rat	2 h cont inf	0,189	0,0667	[56]
Dantrolene	Rat	2 h cont inf	0,0838	0,0297	[56]
Diazepam	Rat	2 h cont inf	0,847	0,805	[56]
Diphenylhydramine	Sheep	SS (adults)	3,4	3,4	[78]
Diphenylhydramine	Sheep	SS (30 d lambs)	4,9	6,6	[78]
Diphenylhydramine	Sheep	SS (10 d lambs)	5,6	6,6	[78]
EAB515	Rat	15 h	0,18	0,08	[51]
Flavopiridol	Rat	2 h cont inf	0,216	0,0525	[56]
Fleroxacin	Rat	2 h cont inf	0,283	0,25	[56]
Fleroxacin	Rat	SS	0,42	0,15	[79]
Ganciclovir	Rat	6 h cont inf	0,0647	0,0711	[61]
Genistein	Rat	2 h cont inf	0,589	0,181	[56]
Lamotrigine	Rat	SS	1,5	1	[62]
Loperamide	Rat	2 h cont inf	0,0376	0,00886	[56]
Metoclopramide	Rat	6 h cont inf	0,169	0,235	[61]
Midazolam	Rat	2 h cont inf	1,35	2,19	[56]
Morphine	Rat	AUC	0,197	0,51	[80]
M6G	Rat	AUC	0,029	0,56	[80]
N-desmethylclozapine	Rat	6 h cont inf	0,0151	0,01	[61]
Norfloxacin	Rat	SS	0,033	0,034	[79]
Ofloxacin	Rat	SS	0,23	0,12	[79]
Oxaliplatin	Nonhuman primate	AUC	0,65	5,3	[74]
Perfloxacin	Rat	2 h cont inf	0,389	0,199	[56]
Perfloxacin	Rat	SS	0,37	0,15	[79]
Phenytoin	Rat	2 h cont inf	0,396	0,447	[56]
Phenytoin	Rat	AUC	0,2	0,85	[81]
Probenecid	Rat	SS	0,6	0,2	[82]
Quinidine	Rat	2 h cont inf	0,0911	0,026	[56]
Quinidine	Rat	6 h cont inf	0,0969	0,0459	[61]
Risperidone	Rat	2 h cont inf	0,124	0,0787	[56]
Risperidone	Rat	6 h cont inf	0,0913	0,0422	[61]
Salicylate	Rat	SS	0,5	0,1	[82]
SDZ EAA 494	Rat	AUC	0,17	0,11	[83]
Sertraline	Rat	2 h cont inf	0,832	1,85	[56]
Stavudine	Rat	SS	0,5	0,3	[84]
Stavudine	Rat	SS	0,6	0,6	[52]
Sulpiride	Rat	2 h cont inf	0,0499	0,0219	[56]
Thiopental	Rat	2 h cont inf	0,599	0,911	[56]
Thiopental	Rat	6 h cont inf	0,0663	0,0663	[61]
Tiagabine	Rat	AUC	0,011	0,011	[85]
Verapamil	Rat	2 h cont inf	0,333	0,0786	[56]
YM992	Rat	SS	1,7	1,4	[86]
Zidovudin	Rabbit	AUC	0,17	0,08	[50]
Zidovudin	Rabbit	SS	0,29	0,19	[87]
Zidovudin	Rhesus Monkey	SS	0,27	0,15	[88]
Zidovudin + probenecid	Rabbit	AUC	0,19	0,1	[50]
Zolpidem	Rat	2 h cont inf	0,475	0,447	[56]