Fig. 6.
The effect of the combined administration of WAY100635 and LSP1-2111 on MK-801-induced hyperactivity in mice. Concomitant administration of LSP1-2111 with WAY100635, 5HT1A receptor antagonist at a low dose at 0.1 mg/kg (and at the higher dose 3 mg/kg (b). LSP1-2111 and WAY100635 were given 45 min before MK-801. Doses in milligrams are indicated in parentheses. Locomotor activity was measured immediately after psychostimulant agent administration. Bars represent means ± SEM. # P < 0.001 versus the control group,**P < 0.01 versus MK-801 and at least @ P < 0.02 versus the MK-801 + LSP1-2111-treated group