Fig. 7.

The effect of the combined administration of (R)-(+)-8-Hydroxy-DPAT hydrobromide and LSP1-2111 on MK-801-induced hyperactivity in mice. Concomitant administration of LSP1-2111 with (R)-(+)-8-Hydroxy-DPAT, agonist at a low dose of 0.01 mg/kg (a) and at the higher dose of 0.1 mg/kg (b). LSP1-2111 was given 45 min, and (R)-(+)-8-Hydroxy-DPAT hydrobromide was given 15 min before MK-801 administration. Doses in milligrams are indicated in parentheses. Locomotor activity was measured immediately after psychostimulant agent administration. The bars represent means ± SEM. ^# P < 0.001 versus the control group, *P < 0.01 versus MK-801-treated group