Fig. 8.
The effect of the combined administration of WAY100635 and (R)-(+)-8-Hydroxy-DPAT hydrobromide on LSP1-2111 action in amphetamine-induced hyperactivity in mice. Locomotor activity of mice habituated to activity cages. Concomitant administration of LSP1-2111 with WAY100635, 5HT1A receptor antagonist (at a dose of 0.1 mg/kg) (a) and 8-OH-DPAT, agonist (at a dose of 0.01 mg/kg) (b). LSP1-2111 and WAY100635 were given 45 min, and (R)-(+)-8-Hydroxy-DPAT hydrobromide was given 15 min before amphetamine administration. Doses in milligrams are indicated in parentheses. Locomotor activity was measured immediately after psychostimulant agent administration. The bars represent means ± SEM. # P < 0.001 versus the control group; **P < 0.01 versus amphetamine group; and @ P < 0.009 versus the AMPH + LSP1-2111-treated group