Table 1.

Selected ω-conotoxins targeting different Ca_V channel subtypes.

Peptide	Conus Specie	Sequence a	Subtype Targeted	Reference
ω-GVIA	C. geographus	CKSOGSSCSOTSYNCCR-SCNOYTKRCY* (4)	N-type	[16]
ω-MVIIA	C. magus	CKGKGAKCSRLMYDCCTGSC--RSGKC* (5)	N-type	[17]
ω-MVIIC	C. magus	CKGKGAPCRKTMYDCCSGSCGRR-GKC* (6)	P/Q/N-type	[18]
ω-CVIA	C. catus	CKSTGASCRRTSYDCCTGSC--RSGRC* (4)	N-type	[19]
ω-CVIB	C. catus	CKGKGASCRKTMYDCCRGSC--RSGRC* (6)	N/P/Q-type	[19]
ω-CVIC	C. catus	CKGKGQSCSKLMYDCCTGSCSRR-GKC* (5)	N/P/Q-type	[19]
ω-CVID	C. catus	CKSKGAKCSKLMYDCCSGSCSGTVGRC* (4)	N-type	[19]
ω-TVIA	C. tulipa	CLSOGSSCSOTSYNCCR-SCNOYSRKCR* (4)	N-type	[20]
ω-TxVII	C. textile	CKQADEPCDVFSLDCCTGIC---LGVCMW* (−3)	L-type	[21,22]
ω-SVIA	C. striatus	CRSSGSPCGVTS-ICC-GRC--YRGKCT* (4)	poor activity	[8]
ω-SVIB	C. striatus	CKLKGQSCRKTSYDCCSGSCG-RSGKC* (5)	P/Q-type	[8]
SO-3	C. striatus	CKAAGKPCSRIAYNCCTGSC--RSGKC* (5)	N-type	[12]

^aAlmost all ω-conotoxins are C-terminally amidated (*), each net positive/negative charge is indicated in the braces after the sequence of the corresponding ω-conotoxin. The disulfide bridges motif of ω-conotoxins and its 4 loops (^Δ) are also displayed above the sequences. Hydroxyproline residues are denoted by the letter O.