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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Annu Rev Genet. 2012 Sep 4;46:371–396. doi: 10.1146/annurev-genet-110711-155456

Table 1.

Genes identified from forward genetic screens whose loss of function causes neurodegeneration

Gene Defect Protein function/human homolog Related disease Reference
drd Phototaxis Unknown (70)
sws Brain histology NTE SPA39 (67)
kdn Bang-sensitive Citrate synthase (57)
tko Bang-sensitive Mitochondrial ribosomal protein S12 (77)
bgm Short life span VLCFA acyl-CoA synthetase ALD (110)
Tpi Short life span Triosephosphate isomerase TPI deficiency (58)
Atpα Short life span Na+/K+ ATPase Dystonia 12 (127)
rdgB ERG Nir2 (68)
nmnat ERG Nmnat Wallerian degeneration (207)