Table 2. Correlations with Endogenous Hormone Variables in Controls (n = 198), NYUWHS, 1985-1994.

	Estrone, pg/mL	Total estradiol, pg/mL	SHBG, nmol/L	Percent free estradiol	Percent of estradiol bound to SHBG	Bioavailable estradiol ⁴, pg/mL
Correlations between serum hormones ¹
Estrone, pg/mL	1.00
Total estradiol, pg/mL	0.76**	1.00
SHBG, nmol/L	−0.19**	−0.22**	1.00
Percent free estradiol	0.18*	0.13	−0.76**	1.00
Percent of estradiol bound to SHBG	−0.23**	−0.23**	0.91**	−0.70**	1.00
Bioavailable estradiol, pg/mL	0.75**	0.98**	−0.41**	0.29**	−0.43**	1.00

Correlations with baseline risk factors ¹
BMI, kg/m²	0.27*	0.41 **	−0.30**	0.29**	−0.33**	0.46**
Total cholesterol, mg/dl	−0.16	−0.11	−0.20	−0.04	−0.24	−0.05
HDL-cholesterol, mg/dl	−0.10	−0.01	0.40**	−0.42**	0.38**	−0.10
LDL-cholesterol, mg/dl	−0.18	−0.17	−0.26*	0.05	−0.27*	−0.10
Alcohol consumption, glasses/day	−0.17*	−0.11	0.04	−0.16	0.05	−0.12
Physical activity, met-hours/week
(Vigorous activity + walking)	−0.06	−0.14	0.02	0.06	0.09	−0.14
Category-specific median hormone values ²
Hypertension status
No (n = 170)	22.58	6.89	61.40	1.12	38.10	4.33
Yes (n = 27)	37.59	11.59	55.66	1.18	34.23	7.66
P value ³	<0.01	<0.01	0.10	0.16	0.03	<0.01
Current smokers
No (n = 146)	23.70	7.17	59.71	1.13	37.49	4.56
Yes (n = 36)	27.20	8.52	57.31	1.15	36.54	5.54
P value ³	0.09	0.27	0.25	0.19	0.21	0.25
Family history of MI
No (n = 114)	23.76	7.12	61.09	1.12	38.07	4.49
Yes (n = 71)	26.73	8.31	59.08	1.16	36.69	5.33
P value ³	0.24	0.18	0.43	0.10	0.25	0.15

Pearson correlation coefficients based on log-transformed values. One control with unknown BMI was excluded from the analyses. * 0.01 ≤ p < 0.05, ** p < 0.01

Median values of endogenous hormone variables by categorical risk factors of CHD.

p value for T-test based on log-transformed hormone values.

⁴

Bioavailable estradiol [computed as total estradiol times (1 minus the percent of estradiol bound to SHBG)].