Table 3. Odds Ratios of Coronary Heart Disease for Tertiles of Serum Levels of Total, Bioavailable, and Percent Free Estradiol, SHBG, and Estrone in Postmenopausal Women (NYUWHS, 1985-1994).

	n		OR for CHD (95% CI)
	Control	Case	Model 1 ¹	Model 2 ²	Model 3 ³
Estrone, pg/mL
5-17	67	35	1.00	1.00	1.00
18-27	73	21	0.51 (0.26-1.02)	0.41 (0.19-0.88)	0.32 (0.14-0.73)
28-86	57	42	1.34 (0.74-2.43)	0.86 (0.43-1.71)	0.76 (0.37-1.55)
P for trend			0.48	0.40	0.22
Continuous scale (log₂)			1.11 (0.83-1.48)	0.87 (0.62-1.21)	0.80 (0.56-1.14)
Total estradiol, pg/mL
1-4	67	27	1.00	1.00	1.00
5-7	69	24	1.28 (0.67-2.44)	0.78 (0.39-1.58)	0.73 (0.35-1.52)
8-74	62	48	1.84 (1.00-3.38)	1.20 (0.58-2.49)	1.20 (0.57-2.55)
P for trend			0.09	0.81	0.70
Continuous scale (log₂)			1.27 (0.96-1.69)	0.96 (0.69-1.34)	0.93 (0.66-1.32)
SHBG, nmol/L
7.9-43.0	60	39	1.00	1.00	1.00
43.1-63.4	61	36	0.88 (0.49-1.56)	1.44 (0.72-2.88)	1.40 (0.68-2.91)
63.5-178.0	77	24	0.50 (0.28-0.92)	1.13 (0.51-2.50)	1.08 (0.48-2.44)
P for trend			<0.01	0.55	0.46
Continuous scale (log₂)			0.59 (0.42-0.83)	0.88 (0.57-1.35)	0.85 (0.54-1.32)
Percent free estradiol
0.70-1.07	77	30	1.00	1.00	1.00
1.08-1.21	60	31	1.32 (0.73-2.40)	0.82 (0.42-1.62)	0.82 (0.40-1.68)
1.22-1.81	61	38	1.58 (0.89-2.82)	0.87 (0.42-1.81)	0.85 (0.40-1.83)
P for trend			0.13	0.41	0.35
Continuous scale (log₂)			2.20 (0.78-6.21)	0.55 (0.13-2.29)	0.48 (0.10-2.24)
Bioavailable estradiol (pg/mL)
0.53-2.88	71	28	1.00	1.00	1.00
2.89-4.84	72	26	0.99 (0.53-1.88)	0.68 (0.33-1.37)	0.62 (0.30-1.30)
4.85-41.63	55	45	2.10 (1.13-3.90)	1.09 (0.51-2.30)	1.03 (0.47-2.24)
P for trend			0.03	0.79	0.71
Continuous scale (log₂)			1.32 (1.02-1.72)	0.96 (0.69-1.33)	0.94 (0.67-1.32)

ORs adjusted for matching factors.

ORs additionally adjusted for baseline hypertension status, BMI, and serum total and HDL cholesterol.

ORs adjusted for variables in models 1 and 2 and for smoking status (current vs. past or never), family history of MI, physical activity, and alcohol consumption.