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. Author manuscript; available in PMC: 2013 May 24.
Published in final edited form as: Nature. 2012 Feb 22;485(7396):55–61. doi: 10.1038/nature10912

Figure 1. Ribosome profiling reveals mTOR-dependent specialized translational control of the prostate cancer genome.

Figure 1

a, Representative comparison of mRNA abundance and translational efficiency after a 3-h treatment with an ATP site inhibitor (PP242) versus an allosteric inhibitor (rapamycin). b–d, Free energy, length and percentage G+C content of the 5′ UTRs of mTOR target versus non-target mRNAs (error bars indicate range, non-target n = 5,022, target n = 144, two-sided Wilcoxon). e, Functional classification of translationally regulated mTOR-responsive mRNAs. f, Chemical structure of INK128. g, Representative western blot from three independent experiments of mTOR-sensitive invasion genes in PC3 cells after a 48-h drug treatment. Rapa, rapamycin.