Figure 6.

Graphical representation of the hereditary breast cancer signaling pathway and other pathways (P53, BRCA1, ATR) involved in DNA damage and repair that are enriched for SNPs associated with increased risk of developing breast cancer.

Notes: Gene symbols in red font represent genes containing SNPs associated with an increased risk of developing breast cancer. Gene symbols in black font represent novel genes not reported in GWAS. Dual ring circles indicate complex regulation involving many genes. Lines and arrows indicate direction of regulation. Biological activities are indicated in the text mapped to rectangular shapes. Information on association of individual SNP-containing genes with individual subtypes of breast cancer is provided in Table B as supplementary material.