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. 2013 Apr 5;288(21):15046–15056. doi: 10.1074/jbc.M113.466136

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Involvement of MEK and ERK in hnRNP-K-induced cell migration. Cells treated with MEK1/MEK2 inhibitor, U0126, showed decrease in ERK (p44/42). Increase in MMP-3 in hnRNP-K-overexpressing cells was compromised by treatment with the inhibitor (A). ERK1/ERK2 inhibitor FR180204 resulted in decreased level of hnRNP-K confirming cross-talk between MEK, ERK, and hnRNP-K as proposed in the model (Fig. 7). Treatment of hnRNP-K-overexpressing cells with MMP-3 inhibitor resulted in their decreased invasion capacity.