FIGURE 5.

Orientation of residues 707-714 within the A2 subunit. Schematic representation of the (A) A2 subunit of FVIII (PDB code 2R7E) with residues 555–571 in red and residues 707-714 in orange stick representation. B, residues 707-714 in stick representation with oxygen in red, nitrogen in blue, and sulfur in yellow. Residues on the 558-loop found to be important for FIXa binding and function are highlighted in green, and Cys⁶³⁰, which forms an essential disulfide bond with Cys⁷¹¹ is highlighted in yellow.