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. 2013 Apr 15;288(21):15131–15141. doi: 10.1074/jbc.M113.455535

FIGURE 4.

FIGURE 4.

Lgr4-deficient mice are more sensitive to LPS-induced septic shock. A, survival curve of wild-type and Lgr4 null mice after LPS-induced septic shock. Age- and sex-matched Lgr4+/+ (n = 10) and Lgr4−/− (n = 12) mice (8–12 weeks old) were injected intraperitoneally with 20 mg/kg LPS and monitored every 2 h for 48 h. Results are plotted as a percentage of total numbers. B, serum concentrations of TNF-α, IL-6, and IL-1β in wild-type and Lgr4 null mice at 2 h after injection of LPS. Mouse TNF-α, IL-6, and IL-1β in serum were obtained at 2 h after injection of LPS for ELISA. *, p < 0.05; **, p < 0.01 (two-tailed Student's t test). Data are representative of two (A) or three (B) independent experiments. Error bars, S.D.