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. 2013 Apr 5;288(21):15181–15193. doi: 10.1074/jbc.M112.446534

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Co-expression of Amot130 and AIP4 inhibits cell accumulation. A, immunoblot (IB) analysis of the protein levels of YFP-tagged Amot130 and mCherry-tagged AIP4 from lysates prepared from MDA-MB-468 cells stably expressing with and without these proteins. These cells expressing either control (♦), mCherry-AIP4 (■), YFP-Amot130 (▴), or mCherry-AIP4 and YFP-Amot130 (●) were plated in triplicate and counted after the indicated days of growth in DMEM with 10% (B) or 0% (C) serum. Data represent the average of three independent experiments. D, model depicting the proposed role of Amot130 in rewiring AIP4 from inducing the degradation of LATS1 to promoting the inhibition of YAP and cell growth. Error bars represent ± S.D. ***, p < 0.005; *, p < 0.05.