TABLE 1.

Statistics of the final 20 best structures of Csk-SH2 and Cbp (289–321)

NOE upper distance limits
Total	2935
Intraresidue (|i − j| = 0)	604
Sequential (|i − j| = 1)	779
Medium range (1 〈|i − j | >5)	552
Long range (|i − j| > = 5)	1000
Intermolecular	202
Hydrogen bonds	33
Disulfide bond	1
Dihedral angle restraints	230
Distance restraint violations
Number >0.2 Å	0
Mean r.m.s. violations from distance restraints	0.0043 ± 0.0005 Å
Dihedral angle restraint violations
Number >5°	0
Mean r.m.s. violations from dihedral angle restraints	0.3307 ± 0.0655°
Ramachandran statistics
Residues in preferred regions	93.4%
Residues in allowed regions	4.8%
Residues in disallowed regions	1.8%
r.m.s deviation to the mean coordinatesa
Backbone atoms	0.26 ± 0.04 Å
Heavy atoms	0.68 ± 0.05 Å

^a Pairwise r.m.s.d. was calculated for residues 80–172 and 296–318 among 20 refined structures.