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. 2013 Mar 14;133(2):298–308. doi: 10.1093/toxsci/kft069

Fig. 4.

Fig. 4.

HU induced activation of p38 MAPK. (A) Western blot analysis of total protein expression of p38 MAPK at 0.5, 3, and 6h after treatment with HU at 400mg/kg (L) or 600mg/kg (H) is shown in the upper panel; the lower panel depicts the scan densitometry quantification of p38 MAPK. (B) Western blot analysis of phosphorylated p38 MAPK at 0.5, 3, and 6h after treatment with HU at 400mg/kg (L) or 600mg/kg (H) is shown in the upper panel; the lower panel depicts the scan densitometry quantification of phospho-p38 MAPK. Phospho-p38 MAPK expression was significantly different from control in embryos 3h after treatment with HU at 600mg/kg. Each bar (mean ± SEM) represents embryos from six sets of pooled litters, with two litters per pool. *, significantly different from saline (control) group at the same time point (†p < 0.01, Dunnett’s test).