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. 2013 Mar 14;133(2):298–308. doi: 10.1093/toxsci/kft069

Fig. 7.

Fig. 7.

Nuclear intensity means of phospho-p38 MAPK in different regions of GD9 embryos. The quantification of nuclear phospho-p38 MAPK immunoreactivity by intensity mean in GD9 embryos exposed to saline or HU at 400 or 600mg/kg in different regions is presented for the RNE (A), CNE (B), NT (C), somite (D), and heart (E). Values were normalized to the corresponding saline control and expressed as fold changes. n = 5. Asterisks, daggers, and double daggers denote a significant difference from saline control at the same time point (*p < 0.05; †p < 0.01; ‡p < 0.001, Dunnett’s test). Panel (F) illustrates the regional differences in nuclear phospho-p38 MAPK expression found in RNE and CNE of embryos exposed to HU at 600 mg/kg. RNE was significantly different than NT (*p < 0.05), somite, and heart (†p < 0.01); CNE was significantly different than heart (*p < 0.05, Tukey’s multiple comparison test).