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. 2012 May 1;1(2):66–121. doi: 10.7453/gahmj.2012.1.2.012

Figure 20.

*240 mg Diltiazem HCI taken daily by 75-year-old man (FH) after getting up (left) or during an interruption of sleep (right).

Individualized blood pressure chronotherapy. Lower circadian double amplitude (2A) and MESOR (M) after switching treatment time from 08:30 (left) to 04:30 (right).* The usefulness of a chronobiologic approach is supported by the demonstration that treatment with antihypertensive drugs can be optimized by timing. The same dose of the same drug can have different effects on the MESOR and circadian amplitude of the same patient's blood pressure when it is administered daily at a different circadian stage as seen by the naked eye and documented by parameter tests.