Table 4.

Trials with IM ziprasidone.

Authors	Zipr. dose (mg/day)	Comparator dose (mg/day)	n	Duration	Efficacy
Brook et al72	Ziprasidone IM 5–60 mg up to 3d. than oral 80–200 mg	Haloperidol IM 2,5–10 mg up to 3 days than oral 10–80 mg	Zipr (n = 90) Halo(n = 42)	1 w.	Reduction in BPRS total, BPRS agitation and CGI-S
Daniel et al74	Ziprasidone IM 2 mg	Ziprasidone IM 20 mg	Zipr 2 mg (n = 38) Zipr 20 mg (n = 41)	24 h	20 mg dose reduced symptom of acute agitation. Both doses well tolerated
Lesem et al76	Ziprasidone IM 2 mg	Ziprasidone IM 10 mg	Zipr 2 mg (n = 51) Zipr 10 mg (n = 63)	24 h	10 mg dose more effective in reducting agitation
Daniel et al72	Ziprasidone IM 5–10–20 mg up to 3 days than oral	Haloperidol IM 10–20 mg up to 3 days than oral	Zipr (n = 206) Halo(n = 100)	1 w.	Equivalent efficacy Low burden of movement disorders
Brook et al73	Ziprasidone IM 10–20 mg up to 3 days than oral 80–160 mg	Haloperidol IM 2,5–5 mg up to 3 days than oral 5–20 mg	Zipr (n = 429) Halo (n = 138)	6 w.	Ziprasidone offers Important efficacy and tolerability
Preval et al77	Ziprasidone IM 20 mg	Various doses conventional antipsychotic	Zipr (n = 110) Halo (n = 9)	2 h	Ziprasidone effective for severe agitation; may reduce time in restrain
Kohen et al78	Ziprasidone IM 20 mg	Haloperidol w/wth lorazepam	Zipr (n = 15) Halo (n = 20)	2 h	Simialrly effective in elderly

Abbreviations:

^*BPRS, brief psychiatric rating scale; CGI-S, clinical global impressions-severity scale.