Table 1.
Results of direct curve fitting of the exponential and the Gompertzian growth models to tumour volume data from two patients
|
Patient (year of birth) |
Tumour type |
Tumour (V cm3) |
Number of data points |
Growth model |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Exponential |
Gompertzian |
|||||||||
| SGR0(%/day) | Year of formation | r2 | SGR0(%/day) | λ (1/d) | Year of formation | r2 | ||||
| 1 (1952) |
Liver metastases from a primary midgut carcinoid |
A (614) |
8 |
0.14 |
1947 |
0.972 |
1.1 |
0.0004 |
1983 |
0.988 |
| B (171) |
8 |
0.15 |
1956 |
0.992 |
0.2 |
0 |
1956 |
0.989 |
||
| C (8) |
3 |
0.22 |
1971 |
1.000 |
0.3 |
0 |
1976 |
0.954 |
||
| D (9) |
4 |
0.27 |
1978 |
0.997 |
1.3 |
0.0005 |
1991 |
1.000 |
||
| E (4) |
2 |
0.33 |
1982 |
1.000 |
- |
- |
- |
- |
||
| F (3) |
2 |
0.31 |
1982 |
1.000 |
- |
- |
- |
- |
||
| 2 (1941) |
Lung metastases from a primary renal cell carcinoma |
A (82) |
3 |
0.32 |
1973 |
0.998 |
3.8 |
0.0014 |
1992 |
1.000 |
| |
|
B (635) |
19 |
0.24 |
1968 |
0.992 |
0.5 |
0.0001 |
1977 |
0.993 |
| |
|
C (489) |
12 |
0.33 |
1976 |
0.939 |
0.4 |
0 |
1977 |
0.938 |
| |
|
D (54) |
7 |
0.38 |
1980 |
0.986 |
1.8 |
0.0006 |
1991 |
0.990 |
| |
|
E (8) |
6 |
0.14 |
1953 |
0.798 |
0.1 |
0 |
1953 |
0.791 |
| |
|
F (11) |
5 |
0.22 |
1970 |
0.946 |
0.4 |
0.0001 |
1978 |
0.944 |
| G (7) | 4 | 0.39 | 1983 | 0.998 | 0.5 | 0 | 1987 | 0.970 | ||
SGR0, r, and λ are the SGR value at the time of tumour formation, the correlation coefficient, and the Gompertzian growth deceleration constant, respectively. Curve fitting of the Gompertzian model was not possible for liver tumours E and F because too few data points were available. V: Maximum tumour volume.