Figure 2.

Inter-patient assessments of CARM1 levels. Case matched samples are shown for the indicated histo-pathological tumor type (normal, DCIS, invasive or metastatic) and molecular subtypes (Triple negative, HER2+ and Luminal A). Tissues from individual cases are stacked in columns in the order of increasing severity. A. Representative stages of progression and the representative differential expression of normal to invasive. We observe high levels of CARM1, even within the adjacent normal, which may indicate pre-cancerous upregulation. B. Representative stages of progression from normal to DCIS to Invasive. Again, we note high levels of CARM1 in the adjacent normal; however, we do not always observe increasing expression with severity of pathology. There are significant associations with sub-cellular localization, indicating the CARM1 levels may be higher prior to carcinogenesis but localization changes with function throughout the process.