Table 1.

SNPs associated with serum urate concentrations in individuals of European ancestry

SNP	Chr.	bp (Build 36)	Closest gene	GRAIL gene	A1	A2	Freq. A1	Serum urate (mg/dl)			Gout
								Effect	s.e.	P value	OR	P value
Discovered loci described previously
rs1471633	1	144435096	PDZK1	PDZK1	A	C	0.46	0.059	0.005	1.2 × 10−29	1.03	2.8 × 10−1
rs1260326	2	27584444	GCKR	GCKR	T	C	0.41	0.074	0.005	1.2 × 10−44	1.14	8.2 × 10−6
rs12498742	4	9553150	SLC2A9	SLC2A9	A	G	0.77	0.373	0.006	0b	1.56	1.9 × 10−31
rs2231142	4	89271347	ABCG2	ABCG2	T	G	0.11	0.217	0.009	1.0 × 10−134	1.73	1.7 × 10−39
rs675209	6	7047083	RREB1	RREB1	T	C	0.27	0.061	0.006	1.3 × 10−23	1.09	1.1 × 10−2
rs1165151	6	25929595	SLC17A1	SLC17A3	T	G	0.47	−0.091	0.005	7.0 × 10−70	0.86	5.3 × 10−7
rs1171614	10	61139544	SLC16A9	SLC16A9	T	C	0.22	−0.079	0.007	2.3 × 10−28	0.91	1.7 × 10−2
rs2078267	11	64090690	SLC22A11	SLC22A11	T	C	0.51	−0.073	0.006	9.4 × 10−38	0.88	2.3 × 10−5
rs478607	11	64234639	NRXN2	SLC22A12	A	G	0.84	−0.047	0.007	4.4 × 10−11	0.97	4.1 × 10−1
rs3741414	12	56130316	INHBC	INHBE	T	C	0.24	−0.072	0.007	2.2 × 10−25	0.87	2.7 × 10−4
New loci
rs11264341	1	153418117	TRIM46	PKLR	T	C	0.43	−0.050	0.006	6.2 × 10−19	0.92	7.4 × 10−3
rs17050272	2	121022910	INHBB	INHBB	A	G	0.43	0.035	0.006	1.6 × 10−10	1.03	3.9 × 10−1
rs2307394a	2	148432898	ORC4L	ACVR2A	T	C	0.68	−0.029	0.005	2.2 × 10−8	0.94	6.3 × 10−2
rs6770152	3	53075254	SFMBT1	MUSTN1	T	G	0.58	−0.044	0.005	2.6 × 10−16	0.90	3.0 × 10−4
rs17632159	5	72467238	TMEM171	TMEM171	C	G	0.31	−0.039	0.006	3.5 × 10−11	0.91	6.0 × 10−3
rs729761	6	43912549	VEGFA	VEGFA	T	G	0.30	−0.047	0.006	8.0 × 10−16	0.87	4.1 × 10−5
rs1178977	7	72494985	BAZ1B	MLXIPL	A	G	0.81	0.047	0.007	1.2 × 10−12	1.14	6.7 × 10−4
rs10480300	7	151036938	PRKAG2	PRKAG2	T	C	0.28	0.035	0.006	4.1 × 10−9	1.09	6.5 × 10−3
rs17786744	8	23832951	STC1	STC1	A	G	0.58	−0.029	0.005	1.4 × 10−8	0.93	2.1 × 10−2
rs2941484	8	76641323	HNF4G	HNF4G	T	C	0.44	0.044	0.005	4.4 × 10−17	1.04	1.7 × 10−1
rs10821905	10	52316099	A1CF	ASAH2	A	G	0.18	0.057	0.007	7.4 × 10−17	1.09	2.6 × 10−2
rs642803a	11	65317196	OVOL1	LTBP3	T	C	0.46	−0.036	0.005	2.9 × 10−13	0.90	2.2 × 10−4
rs653178	12	110492139	ATXN2	PTPN11	T	C	0.51	−0.035	0.005	7.2 × 10−12	0.95	7.3 × 10−2
rs1394125	15	73946038	UBE2Q2	NRG4	A	G	0.34	0.043	0.006	2.5 × 10−13	1.03	3.6 × 10−1
rs6598541	15	97088658	IGF1R	IGF1R	A	G	0.36	0.043	0.006	4.8 × 10−15	1.04	2.5 × 10−1
rs7193778	16	68121391	NFAT5	NFAT5	T	C	0.86	−0.046	0.008	8.2 × 10−10	0.92	3.4 × 10−2
rs7188445	16	78292488	MAF	MAF	A	G	0.33	−0.032	0.005	1.6 × 10−9	0.95	1.1 × 10−1
rs7224610	17	50719787	HLF	HLF	A	C	0.58	−0.042	0.005	5.4 × 10−17	0.96	1.6 × 10−1
rs2079742a	17	56820479	BCAS3	C17orf82	T	C	0.85	0.043	0.008	1.2 × 10−8	1.04	3.5 × 10−1
rs164009a	17	71795264	QRICH2	PRPSAP1	A	G	0.61	0.028	0.005	1.6 × 10−7	1.08	8.6 × 10−3

P values are corrected for inflation using genomic control. Median imputation quality was calculated across all cohorts for urate concentration–associated SNPs in the overall sample and ranged from 0.83 to 1 (median of 0.98). Allele frequencies are presented for the discovery sample. Gout estimates are provided for the combined discovery and validation samples. Sample sizes available for the individual SNPs are listed in Supplementary Table 6. Chr., chromosome; A1, allele 1, effect allele; freq., frequency; s.e., standard error.

^aThese SNPs met one but not both criteria required for replication.

^bP value < 1 × 10⁻⁷⁰⁰.