Table 2.

Urate concentration–associated SNPs from secondary analyses

SNP	Chr.	bp (Build 36)	Gene	A1	A2	Freq. A1	Serum urate (mg/dl)			Gout
							Effect	s.e.	P value	OR	P value
Urate transporter candidate analysis
rs4149178a	6	43380166	SLC22A7	A	G	0.84	−0.034	0.007	1.2 × 10−6	0.95	2.2 × 10−1
Functional association network analysis
rs4970988a	1	149216686	ARNT	A	G	0.36	−0.028	0.005	1.0 × 10−7	0.96	2.1 × 10−1
rs7976059	12	50537539	ACVR1B-ACVRL1	T	G	0.35	0.032	0.005	1.9 × 10−9	0.95	1.8 × 10−1
rs7953704	12	121191945	B3GNT4	A	G	0.47	−0.029	0.005	2.6 × 10−8	0.95	1.6 × 10−1

Allele frequencies are presented for the discovery sample. Chr., chromosome; A1, allele 1, effect allele; freq., frequency; s.e., standard error.

^aThese SNPs met one but not both criteria required for replication.