Table 3.
Nominally significant associations between urate concentration–associated SNPs and FEUA
| SNP | Closest gene | A1 | A2 | Serum urate (mg/dl)
|
FEUA (%)
|
|||
|---|---|---|---|---|---|---|---|---|
| Effect | P value | Effect | s.e. | P value | ||||
| rs1260326 | GCKR | T | C | 0.074 | 1.2 × 10−44 | −0.073 | 0.018 | 3.0 × 10−5 |
| rs12498742 | SLC2A9 | A | G | 0.373 | 0a | −0.184 | 0.022 | 1.2 × 10−16 |
| rs2231142 | ABCG2 | T | G | 0.217 | 1.0 × 10−134 | −0.076 | 0.030 | 9.8 × 10−3 |
| rs675209 | RREB1 | T | C | 0.061 | 1.3 × 10−23 | −0.064 | 0.021 | 2.2 × 10−3 |
| rs2078267 | SLC22A11 | T | C | −0.073 | 9.4 × 10−38 | 0.042 | 0.020 | 3.7 × 10−2 |
| rs478607 | NRXN2 | A | G | −0.047 | 4.4 × 10−11 | 0.046 | 0.023 | 4.6 × 10−2 |
| rs1394125 | UBE2Q2 | A | G | 0.043 | 2.5 × 10−13 | −0.059 | 0.023 | 1.1 × 10−2 |
| rs6598541 | IGF1R | A | G | 0.043 | 4.8 × 10−15 | −0.059 | 0.019 | 1.5 × 10−3 |
| rs7193778 | NFAT5 | T | C | −0.046 | 8.2 × 10−10 | 0.086 | 0.032 | 7.2 × 10−3 |
| rs7224610 | HLF | A | C | −0.042 | 5.4 × 10−17 | 0.045 | 0.017 | 9.3 × 10−3 |
Serum urate concentration estimates are provided for the combined discovery and replication sample. Sample size for the SNPs for FEUA ranged from 6,798 to 6,799. A1, allele 1, effect allele; s.e., standard error.
a
P <1 × 10−700.