Table 1.
List of genes up- or down-regulated in the chicken cecum after infection with Salmonella Enteritidis arranged according to their maximal fold up- or down-regulation after infection with wild type Salmonella Enteritidis (column max fold SE wt)
|
Gene |
Max NI# |
Min NI |
Max SE |
Min SE |
Max fold |
WT fold |
SPI1 fold |
|---|---|---|---|---|---|---|---|
| SE wt$ | 4 dpi& | 4 dpi& | |||||
| MMP7 |
0.078 (12) |
0.001 (29) |
8.98 (5) |
0.001 (1) |
5952 (10) |
1578 |
35.2 |
| IgG |
5.02 (25) |
0.006 (2) |
36.7 (25) |
0.009 (1) |
442 (10) |
33.2 |
1.63 |
| IRG1 |
0.005 (2) |
0.001 (11) |
0.69 (5) |
0.003 (1) |
425 (7) |
222 |
4.61 |
| SAA |
0.25 (2) |
0.018 (9) |
15.9 (5) |
0.065 (1) |
382 (5) |
106 |
5.02 |
| ExFABP |
1.06 (18) |
0.150 (9) |
75.3 (5) |
0.369 (1) |
366 (5) |
56.8 |
4.80 |
| IL-22 |
0.005 (12) |
0.0004 (10) |
0.39 (5) |
0.001 (1) |
355 (10) |
46.9 |
2.69 |
| TRAP6 |
0.39 (2) |
0.011 (15) |
5.76 (5) |
0.029 (25) |
194 (5) |
37.3 |
2.19 |
| MRP126 |
0.16 (2) |
0.003 (29) |
1.96 (5) |
0.018 (25) |
194 (11) |
14.3 |
2.11 |
| IFNγ |
0.001 (18) |
0.0001 (11) |
0.035 (5) |
0.0002 (1) |
183 (11) |
62.8 |
1.39 |
| IL1β |
0.018 (18) |
0.002 (1) |
0.74 (5) |
0.002 (1) |
134 (3) |
29.1 |
1.59 |
| iNOS |
0.019 (1) |
0.008 (9) |
1.99 (7) |
0.019 (1) |
151 (7) |
47.9 |
2.84 |
| ES1 |
2.06 (2) |
0.055 (29) |
39.6 (4) |
0.178 (1) |
139 (11) |
17.4 |
2.21 |
| LYG2 |
0.26 (7) |
0.015 (22) |
5.82 (3) |
0.031 (25) |
130 (3) |
24.5 |
3.09 |
| IFIT5 |
0.56 (12) |
0.003 (1) |
1.28 (3) |
0.003 (1) |
124 (3) |
42.4 |
2.62 |
| IL-17 |
0.014 (2) |
0.0003 (29) |
0.095 (3) |
0.001 (22) |
120 (11) |
6.72 |
1.12 |
| AVD |
2.07 (2) |
0.20 (29) |
103.1 (5) |
0.207 (1) |
116 (9) |
29.6 |
3.24 |
| AH221 |
0.73 (18) |
0.12 (1) |
23.4 (5) |
0.119 (1) |
108 (5) |
42.9 |
1.90 |
| serpin B |
0.096 (2) |
0.002 (29) |
0.54 (5) |
0.009 (25) |
101 (5) |
18.4 |
1.45 |
| TGM4 |
0.092 (12) |
0.005 (6) |
0.92 (5) |
0.014 (1) |
68 (6) |
30.4 |
1.99 |
| IgA |
6.04 (18) |
0.003 (2) |
23.4 (22) |
0.005 (3) |
49 (3) |
16.6 |
1.86 |
| EPSTI1 |
0.39 (12) |
0.015 (1) |
0.74 (4) |
0.015 (1) |
33 (3) |
12.9 |
1.40 |
| IL-8 |
0.15 (6) |
0.004 (29) |
1.08 (4) |
0.007 (1) |
31 (11) |
4.54 |
1.24 |
| C3 |
0.092 (2) |
0.019 (10) |
0.78 (11) |
0.044 (1) |
29 (10) |
9.7 |
1.53 |
| mucin-2 |
0.37 (3) |
0.018 (9) |
0.77 (4) |
0.124 (6) |
20 (11) |
1.01 |
0.94 |
| PTGDS |
1.50 (9) |
0.12 (1) |
17.8 (5) |
0.117 (1) |
19 (5) |
14.9 |
1.70 |
| ITGLB2 (CD18) |
0.084 (22) |
0.031 (3) |
0.46 (11) |
0.045 (18) |
14 (11) |
9.40 |
1.04 |
| HPX |
0.19 (7) |
0.025 (12) |
0.91 (5) |
0.071 (25) |
13 (5) |
5.06 |
1.10 |
| ASL2 |
0.46 (2) |
0.15 (29) |
2.26 (4) |
0.289 (1) |
11 (10) |
3.74 |
1.17 |
| HCLS1 |
0.25 (29) |
0.088 (5) |
1.11 (10) |
0.107 (1) |
10 (11) |
5.41 |
1.13 |
| TAP1 |
0.443 (22) |
0.087 (3) |
2.26 (7) |
0.104 (1) |
10 (4) |
13.7 |
1.37 |
| STAT1 |
0.31 (12) |
0.059 (9) |
1.03 (3) |
0.164 (1) |
9.2 (9) |
8.61 |
1.25 |
| RSFR |
0.96 (8) |
0.40 (1) |
7.19 (5) |
0.397 (1) |
9.1 (5) |
6.41 |
1.19 |
| MEG1 |
0.49 (22) |
0.090 (3) |
1.80 (5) |
0.115 (1) |
7.0 (5) |
8.22 |
0.92 |
| STAT3 |
0.64 (18) |
0.37 (3) |
1.28 (7) |
0.537 (5) |
2.2 (3) |
2.91 |
1.00 |
| AQP8 |
33.4 (22) |
14.9 (1) |
17.6 (25) |
0.290 (5) |
97 (5) |
18.90 |
1.80 |
| ADH1B |
9.46 (7) |
3.42 (2) |
4.66 (25) |
0.100 (5) |
75 (5) |
16.23 |
1.55 |
| FABP1 |
6.11 (22) |
1.98 (11) |
8.48 (22) |
0.119 (5) |
47 (5) |
5.49 |
1.32 |
| RALDH1 |
18.6 (22) |
9.17 (2) |
12.6 (1) |
0.404 (5) |
39 (5) |
12.87 |
1.43 |
| unchar. oxidoreductase |
5.84 (12) |
0.80 (4) |
4.25 (22) |
0.192 (5) |
28 (5) |
7.14 |
1.26 |
| CALB1 |
24.2 (1) |
8.20 (2) |
24.2 (1) |
0.785 (5) |
19 (5) |
13.78 |
1.88 |
| ALDOB |
1.66 (22) |
0.32 (2) |
0.58 (22) |
0.037 (5) |
19 (10) |
6.71 |
0.99 |
| SULT1C3 |
21.9 (4) |
7.20 (29) |
16.0 (1) |
1.081 (5) |
18 (5) |
8.04 |
1.86 |
| HPGD | 4.62 (7) | 1.58 (1) | 2.77 (2) | 0.396 (5) | 10 (7) | 8.87 | 1.29 |
# Maximal or minimal expression levels observed in the non-infected or Salmonella Enteritidis infected chickens as determined in the time-dependent study; numbers in brackets indicate the day of life when the appropriate value was recorded.
$ Maximal fold upregulation or downregulation and the day when recorded in the time-dependent study. The downregulated genes are at the bottom of the table starting with AQP8.
& Fold up or downregulations 4 days post-infection of chickens with wild-type Salmonella Enteritidis and the SPI1 mutant.