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. 2013 May 24;8(5):e63748. doi: 10.1371/journal.pone.0063748

Figure 2. Transmission electron microscopy.

Figure 2

MBS from DAOY (A), UW228 (B) and ONS-76 (C) show a uniform stem-like aspect characterized by a high N:C ratio; nucleus is irregularly shaped and cytoplasm appears sparsely organized with unspecific electron-dense organelles (B) and vacuoles (A). MB cell lines feature a low N:C ratio (D, E): nuclei exhibit an irregular profile and are peripherally located; the cytoplasm is populated by many organelles, such as RER, Golgi apparatus and mitochondria. On the contrary, ONS MB seem to maintain stemness appearance (F) as seen in the high N:C ratio with a kidney-shaped nucleus rimmed by a thin layer of cytoplasm.